The Reactive Species Interactome in Red Blood Cells: Oxidants, Antioxidants, and Molecular Targets

Beyond their established role as oxygen carriers, red blood cells have recently been found to contribute systemic NO and sulfide metabolism act potent circulating antioxidant cells. Emerging evidence indicates that reactive species derived from the of O2, NO, H2S can interact with each other, potentially influencing common biological targets. These interactions encompassed in concept interactome. This review explores potential application interactome understand redox physiology RBCs. It specifically examines how are generated detoxified, Hemoglobin is a key player within RBCs, given its abundance fundamental O2/CO2 exchange, transport/metabolism, sulfur binding/production. Future research should focus on understanding modulation may regulate RBC biology, physiology, effects.